Founding Software Engineer

Nearly all disease will become treatable in our lifetimes. At the same time, drug discovery is quickly becoming an engineering discipline. There has never been a more exciting time for new biotech research to solve humanity’s most fundamental problems.

At Mandolin, we’re building the “last mile” delivery infrastructure to accelerate this unbounded future of cutting-edge drugs — cell/gene therapies and biologics for Alzheimer’s, cancer, schizophrenia, genetic disorders, amongst many others. Reasoning-adept LLMs uniquely unlock the opportunity to bridge this market gap. We’re starting with an “AI knowledge worker” for clinics administering these drugs, and then partnering with health insurers and pharma companies to bring drug breakthroughs to market at scale.

Ultimately, our mission is to substantially extend healthy human lifespans by minimizing the time it takes to bring life-changing drugs to patients.

We’re a lean, aggressive team of former founders set on building a new generational incumbent in healthcare. We’ve raised substantial institutional funding from the best healthcare AI investors like SignalFire, Maverick, and ex-Thrive GP Gaurav Ahuja (including first institutional checks into rocketships like Hims&Hers, Ro, Grow Therapy, Cityblock, and Devoted Health).

Mandolin was founded by Will Yin and Rohit Rustagi — Stanford dropouts and second-time exited founders — alongside teammates from Google, Stanford, Genentech, and others.

Why work at Mandolin?

We’ve found market fit and are building out our founding team very quickly. Reasons to join:

• We have incredible market pull and are already working closely with some of the largest healthcare providers all over the country.

• We’re solving a difficult technical problem, which unlocks a massive $30B+ market opportunity and enormous impact once solved.

• You’ll get to define the future of the company from the ground floor, alongside a world-class team from Stanford, Google, and Palantir.

• We are building an in-office culture in SF, while still being able to hire the best talent from anywhere. We will offer relocation to accommodate our in-office culture.

Who we’re looking for

You’d be a perfect fit for our team if you…

• Are most familiar and comfortable with the 0-to-1 phase. You find it to be your sweet spot.

• Are relentlessly truth-seeking in product and business.

• Are opinionated but considerate.

• You drive toward solving problems at all costs, looking at the bigger picture as well as diving into the details.

• Love building beautiful, complex systems as much as you love moving extremely fast.

What you’ll work on

All founding engineers at Mandolin are full-stack generalists, meaning you’ll get a chance to work across the entire stack (frontend, backend, AI infrastructure, devops). Given the compound nature of our product, we also tend to form short-lived teams around specific projects. You’ll be working closely with our customers and owning complete projects, including:

• Outlining the 0-to-1 of project requirements, goals, and roadmaps from customer problems

• Defining complex agentic architectures in a demanding, highly-regulated industry

• Wrangling a wide variety of cutting-edge agentic AI infrastructure

• Leading end-to-end implementation to deliver fast, high-quality iterations to customers

Qualifications

• 3+ years building production software.

• Strong CS fundamentals and experience with the modern web stack.

• Proficiency with TypeScript and/or Python.

• Extremely excited about building complex agentic AI systems and working with multimodal models.

• Strong intuition for prioritizing between product, business, and technical tradeoffs.

• Experience building 0-to-1 through projects or other startups.

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If this sounds awesome, send us a note at hiring@mandolin.com.